Formulation Optimization of Arecoline Patches

Formulation Optimization of Arecoline Patches

Blog Article

The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate greygasms adhesion and flux.The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), Glandulars and drug.In addition, using terpenes as enhancers could increase the flux of the drug.Menthol showed the highest enhancement effect on the flux of arecoline.